FM 2.0 principle: True metabolic flexibility arises when detox, inflammation, and energy production operate in harmony
Indians develop diabetes, fatty liver, and heart disease at a lower BMI and often carry more fat around the belly with less muscle (the thin-fat phenotype)
What part of the semaglutide pathway do you see as the biggest hurdle today
GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)
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J Endocrinol, 174(2):R1-R6